The use of various organic solvents to tailor the properties of Ibuprofen-glucosamine HCl solid dispersions

Ibuprofen is a Biopharmaceutical classification system class II drug that exhibits poor dissolution rate in the gastrointestinal tract. The aim of the present study is to enhance the dissolution of ibuprofen in presence of glucosamine. To this end, different ratios of ibuprofen:glucosamine were dissolved in various organic solvents to obtain the solid dispersions of ibuprofen-glucosamine mixtures. The solid state analysis of the samples (differential scanning calorimetry, Fourier infrared spectroscopy and x-ray powder diffraction) and the morphology (scanning electron microscope) were investigated. Particle size analysis and in vitro dissolution studies showed that the type of solvent has a significant influence on dissolution rate. Ibuprofen-glucosamine solid dispersions obtained from acetone produced better dissolution compared to that of other organic solvents. The effect of water in binary